Dax really wanted to have a street basketball team enrolled in a big tour of the city of Harlem, and to see his dream come true, he was willing to consume all the money he had piled up to now. An unnecessarily big need because of the unhappy obstacles that he still encounters and being defeated by his life rival, which his team has taken, Dax is at the height of despair.
The sun seems to come out on Dax Street when he meets the god of basketball, the legendary Uncle Drew. Desperate to participate and win out of a tournament to get his hands on the big prize that would take him out of all the trouble, Dax begs Drew to help him and he not only accepts to do that, but also goes on his way with Dax to find his former teammates with whom he would once again form a star team to play on the field. Among these great players we find Shaquille O’Neal, Chris Webber, Reggie Miller, Nate Robinson and Lisa Leslie, and these veterans are ready to show they still know how to make a show.